Thursday, January 28, 2016

Anticipating the international spread of Zika virus from Brazil

In May, 2015, locally acquired cases of Zika virus—an arbovirus found in Africa and Asia-Pacific and transmitted via Aedes mosquitoes—were confirmed in Brazil. The presence of Aedes mosquitoes across Latin America, coupled with suitable climatic conditions, have triggered a Zika virus epidemic in Brazil, currently estimated at 440 000–1 300 000 cases.1 Viraemic travellers have now introduced Zika virus into at least 13 additional countries, where susceptible Aedes mosquitoes have become infected and perpetuated local transmission cycles. In Brazil, a precipitous surge in infants born with microcephaly and the detection of Zika virus RNA in the amniotic fluid of affected newborns has been reported.1 We sought to identify high-risk international pathways for the dispersion of Zika virus and global geographies conducive to autochthonous transmission.
We created a global Zika virus spread model by adapting a seasonal model for dengue that integrates global ecological niche data for Aedes aegypti and albopictus and worldwide temperature profiles.2, 3 In Brazil, we identified airports within 50 km of areas conducive to year-round Zika virus transmission. We mapped the final destinations of international travellers departing from these airports from September, 2014, to August, 2015, using worldwide flight itinerary data from the International Air Transport Association. We used LandScan, a gridded global population dataset, to estimate numbers of people living in geographies at risk for autochthonous Zika virus transmission.
9·9 million travellers departed from the aforementioned Brazilian airports for international destinations, with 65% to the Americas (figure), 27% to Europe, and 5% to Asia. Traveller volumes were greatest to the USA (2 767 337), Argentina (1 314 694), Chile (614 687), Italy (419 955), Portugal (411 407), and France (404 525). China and Angola received the highest volume of travellers in Asia (84 332) and Africa (82 838), respectively. Argentina, Italy, and the USA have more than 60% of their populations residing in areas conducive to seasonal Zika virus transmission, whereas Mexico, Colombia, and the USA have an estimated 30·5, 23·2, and 22·7 million people, respectively, living in areas conducive to year-round transmission.
Thumbnail image of Figure. Opens large image

Figure

Final destinations of travellers departing Brazil by potential for autochthonous Zika transmission
In parallel to the recent experience with chikungunya,4 Zika virus has the potential to rapidly spread across Latin America and the Caribbean. With no vaccine or antiviral therapy available, possible interventions include: personal protection (ie, repellent use) and daytime avoidance of mosquito bites (especially pregnant women until more is known about the association between Zika virus infection and microcephaly); daytime avoidance of mosquito bites among Zika virus-infected individuals to disrupt human to mosquito to human transmission cycles (80% of infected individuals are asymptomatic and the remainder have clinical syndromes overlapping with dengue and chikungunya);5 and community-level mosquito surveillance and control measures. The summer Olympic Games in Brazil in August, 2016, heighten the need for awareness of this emerging virus.
KK is the founder of BlueDot, a social benefit corporation that models global infectious disease threats. MIC, MG, and AW have received employment income from BlueDot. IIB has consulted to BlueDot. We acknowledge support from the Canadian Institutes of Health Research, National Institute of Health, R01 LM010812 , the Wellcome Trust ( #095066 ), the Bill & Melinda Gates Foundation ( OPP1119467, OPP1106023, and OPP1093011 ), and the RAPIDD program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health.

References

  1. European Centre for Disease Prevention and Control. Rapid risk assessment: Zika virus epidemic in the Americas: potential association with microcephaly and Guillain-Barré syndrome. 10 December 2015. ECDC, Stockholm; 2015
  2. Kraemer, MUG, Sinka, ME, Duda, KA et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus. eLife. 2015; 4: e08347
  3. Brady, OJ, Golding, N, Pigott, DM et al. Global temperature constraints on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmission. Parasit Vectors. 2014; 7: 338
  4. Weaver, SC and Lecuit, M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med. 2015; 372: 1231–1239
  5. Duffy, MR, Chen, T-H, Hancock, WT et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009; 360: 2536–2543

Office Market in Houston Melts Down, Watch The Banks!

Wolf Richter wolfstreet.com, www.amazon.com/author/wolfrichter
Commercial real estate is highly leveraged. Debt is everything. The entire math is based on high rental rates and low vacancy rates. Without them, the debts cannot be serviced. But now in Houston, both are shooting in the wrong direction.
OK, Houston’s economy is diversified, they say. The oil bust hurts, and there have been waves of layoffs of highly paid engineers, but it won’t hit the city as bad as the last big oil bust did, they say.
And yet, the amount of office space vacated by companies that are trying to slash their operating expenses and that is now on the market as sublease space has spiked 69% by the end of 2015, to 7.6 million square feet (msf), according to real-estate services firm Savills Studley. And they “continue to sit on the market.”

It’s going to get worse:

New sublease blocks are expected to hit the market in 2016, particularly in the CBD [Central Business District]. Shell is projected to vacate 250,000 sf in One Shell Plaza and EP Energy, likewise, is anticipated to leave 100,000 sf in the Kinder Morgan Building. Shell would likely also shed space at BG Group Place should its pending $70-billion acquisition of BG Group clear governmental hurdles and finalize.
Many large tenants who paid at the very top of the market in the last few years warehoused space in anticipation of continued headcount growth. As a result, many firms had surplus space even prior to the implementation of layoffs in the last year. In 2016, the office market should see more shadow space listings….
Occupancy, after five years in a row of increases, fell by 1.4 msf (“negative absorption”), the biggest decrease in occupancy since 2009. Going forward, M&A and bankruptcies “will contribute to additional negative absorption” and will hit the vacancy rate. It already spiked to 23.2%.

And it’s going to get even worse:

After a tremendous building boom in 2013 and 2014, a total of 17 msf is expected to hit the market over the next few years, with 7.9 msf scheduled for completion in 2016. Only about two-thirds have been pre-leased. Some of these pre-leased properties will enter the shadow inventory as soon as they’re completed. But 5.5 msf has not been leased.
These new buildings will hit the market at the worst possible time, competing with 7.9 msf of sublease space and large amounts of shadow inventory, during a period of negative absorption.
Already the first “see-through buildings” in this cycle are appearing — that infamous phenomenon of vacant and transparent buildings dotting Houston’s business district during the oil bust of the 1980s.
Piedmont Office Realty Trust last year “opened a glassy 11-story building in the heart of the Energy Corridor district without any tenants,” the Wall Street Journal reported. The company’s CEO Don Miller lamented in November during the earnings call that “there’s no real genuine activity in the marketplace.”
And “several notable mistimed projects to be completed this will be under immense pressure,” Savills Studley reported, including:
609 Main. Of its 1,000,000 sf, only 62,000 sf have been leased so far. “Only time will tell whether that space continues to remain vacant after delivery or if the landlord successfully cannibalizes other CBD Class A buildings through new relocation deals.”
And Energy Center Five, scheduled to deliver in April, “remains completely unleased with 524,328 sf available.”
Leasing activity in 2015 plunged 42% to 8.4 msf, the weakest since Financial-Crisis year 2009. While there were some large deals in the fourth quarter, they were “bearish moves”:
Apache Corporation, for example, extended its 524,000-sf lease in Post Oak Central for just one year, pushing back its expiration from December 2018 to December 2019. It executed this extension instead of moving forward on a new development with 6.4 acres of land that it purchased in BLVD Place in 2012.
The quarter’s second largest lease, finalized by Bracewell & Giuliani at Pennzoil Place, was a renewal that saw the law firm downsize by an entire floor to 189,061 sf.
Now the market is in a holding pattern, without real demand, and lots of supply. Savills Studley’s report:
Landlords are feeling the marked reduction in tours, requests for proposals, and ultimately deal volume. Rents appear to be adjusting in spots, but the gap between tenant and landlord expectations has widened.
Many landlords still want to hit or come close to their pro forma financials. In contrast, some area businesses expect rents to adjust on a level that matches the sharp slide in energy pricing.
So overall asking rent edged down 1.6% to $28.99 per square foot, the second quarter in a row of declines. Class A asking rent fell 2.5% to $34.70. But the oncoming flood of sublet supply and new space, while demand is actually declining, will likely lead to “sharper rental rate erosion in future quarters.”
And this is where it gets tricky for banks. Commercial real estate is highly leveraged. Without high rental rates and low vacancy rates, the math won’t work and the debts cannot be serviced. Now both are shooting in the wrong direction.
Last time this happened, it turned into a gigantic mess that helped tear up over 400 Texas banks between 1980 and 1989, including nine of the state’s 10 largest.
So now everyone is hoping for a miraculous turnaround in the price of oil, in addition to healthy growth in the overall US economy, and everything else will follow. They’re hoping for another oil boom, and all that comes with it. But if their wishes come true even modestly, it would very quickly lead to a boom in production and thus an extension of the glut that would destroy the price of oil all over again before it ever gets back to a survivable level. And the shakeout in the real estate bust will simply get worse.
And how are banks that lent to the oil & gas sector dealing with? “All of it is in the gutter.” Read… Banks Much Deeper in the Hole on Oil & Gas Collateral than they Pretend

Feldstein says Fed should let the market fall and keep hiking rates

Central bank should not pause due to stock market declines, Harvard economist says

 

Martin Feldstein thinks talk of a recession is overblown.



WASHINGTON (MarketWatch) — Martin Feldstein, a prominent Harvard economist once on many people’s short-list to lead the Federal Reserve, has a simple message for the U.S. central bank: ignore the stock market.
In an interview with MarketWatch, Feldstein said stocks are overvalued. Any signal from the U.S. central bank that it may pause from its plans to continue raising interest rates would only create the impression that there is a “Fed put” on the market. A put is an option that protects an investor from losses.
In the interview, Feldstein, now 76 and the president emeritus of the National Bureau of Economic Research, sees a risk of higher inflation going forward. He said growing talk of a recession in the U.S. is misguided.
MarketWatch: In a column in the Wall Street Journal in August, you said this about Fed policy: “It is time to escape the unprecedented monetary policy that for a while stimulated demand – but then distorted prices and brought about the current corrections.” Can you unpack that? What is going on?
Feldstein: They introduced unconventional monetary policy, quantitative easing. It was successful in the way that the Fed and [former chairman] Ben Bernanke predicted, in that it raised household wealth by driving investors into equities and increased the value of homes. And in response to that increase in wealth, consumers went out and spent more and that got the economy going. I think it was as simple as that, and it was effective. But, at the same time, these super-low, sustained low interest rates have led to a variety of risk-taking that could cause significant problems going forward. So the stock market got pushed up to a point where the price-to-earnings ratio is about 30% higher than it’s been historically and we’re seeing what that’s doing in terms of falling equity prices and similar things are happening on high-risk debt, and I could go on.
MarketWatch: You want them to tighten more?
Feldstein: I want them to do what the FOMC forecast in December, which is that they would take the rate up by 100 basis points in 2016 and continue to do more in 2017. And even that will still be very easy, accommodative, monetary conditions.
MarketWatch: Won’t financial conditions tighten and the stock market decline?
Feldstein: That’s right, the stock market might decline. But if the stock market is very overvalued we shouldn’t be surprised that, at some point, it has to revert to a more normal level.
MarketWatch: Won’t that damage the economy?
Feldstein: I’d rather it happen slowly, then build up the kind of problems we had in 2006, 2007 and 2008.
MarketWatch: So this is just an adjustment the economy has to make?
Feldstein: The danger, in my mind anyway, is if the Fed keeps interest rates extremely low, if they say, in reaction to the recent decline in equity prices, if they say: “Well maybe we shouldn’t raise interest rates,” that will just be a signal to buy more equities and to push up the price of equities even further and to get things further out of line so when the correction comes, it will be even bigger.
MarketWatch: So asset prices are now overvalued and that has to reverse?
Feldstein: Yes, and making it worse would not be a good thing.
MarketWatch: You’ve been worried about inflation for some time –even pressing Fed Chairwoman [Janet] Yellen when she first took office about it. Haven’t you been wrong so far?
Feldstein: I think I have said it was important for the Fed to make it clear that they cared about inflation. I think I wrote that and I said that in the Economic Club of New York discussion with Janet Yellen [in April 2014]. I’ve also explained, in a Project Syndicate piece, that contrary to what a lot of people say, there hasn’t been a big increase in the money supply, and therefore inflation is unlikely. People have said to me, ‘since we’ve had this explosion of money, why didn’t that create inflation?’ And what I wrote that we haven’t had that explosion of money, what happened was the commercial banks took the opportunity to just leave funds at the Federal Reserve. They didn’t use those funds to expand their lending and to expand the money supply. But I think there is the danger going forward, that, starting where you are today, with an unemployment rate of 5%, if the Fed continues to have negative real short-term rates, that we could see the unemployment rate drifting down below 5% and, at some point, that would start to raise inflation.
MarketWatch: Larry Summers, and others, have argued that the neutral interest rate – the level of interest rates consistent with full employment – is lower now than it used to be. It sounds like you are not buying that.
Feldstein: Yes, I am not a big fan of those arguments. I think it is hard to know. What we know is that actual rates are very low, but we know the Fed has made that happen. So the neutral real rate is not a number you can see in the market, it is a number that economists can try to calculate but I am not persuaded that that number is a negative number or dramatically lower.
MarketWatch: You want the Fed to hike rates steadily, step-by-step toward something like a 3.5% terminal rate?
Feldstein: Assuming that inflation does increase, as the Fed itself predicts, remember that core CPI is at 2.1% relative to 12 months ago, so if someday the price of oil stops falling, we will see actual inflation catch up with the core, so when the inflation rate gets into the 1.5%-2% range, then I think normalization of interest rates means getting interest rates back to, as you say, 3.5% to 4%.
MarketWatch: Do you want them to go steadily, go in March?
Feldstein: I hate to use their expression but it’s data dependent. So it depends on what is happening in the economy. But I wouldn’t take the fall in the equity market as a reason not to stick to their interest rate expansion path because I think that would send a very bad signal to investors that there is a kind of Fed put there and that they don’t have to worry because the stock market only goes up, because that will get it further out of line with reality.
MarketWatch: There has been growing talk about a recession. You don’t sound so worried.
Feldstein: I’m not. We’ve had a weak [fourth] quarter, basically we had a very weak October. We don’t have December numbers yet. If you look at the various forecasts that you and I probably both look at, for the first quarter, there are numbers in the 2.5% range for real GDP, so I don’t see any serious problem. And even the fourth-quarter numbers, which are just estimates at this point, are primarily driven by reductions in inventories and weaker exports. So it is not domestic demand that is doing this.
MarketWatch: If the Fed keep raising rates, won’t the dollar continue to strengthen and hurt manufacturing?
Feldstein: If we look at the impact of the exchange rate on the cost of imports and competitiveness on exports, there is very little in it from the exchange rate. The main thing that has driven the cost of imports has been the energy price, and the government breaks out those two components of what drives the import price index. The competition that supposedly comes from abroad because of the exchange rate is very small relative to the part of the import price index that is driven by energy.
MarketWatch: So commercial real estate is another example of a bubble?
Feldstein: Overvalued. The number I hear is cap rates of around 3%, that is not sustainable.
MarketWatch: Part of your concern is the Fed doesn’t have good tools to combat asset bubbles.
Feldstein: They perhaps could have them if they wanted them, but they certainly don’t use them. They have said that we should have macroprudential policies other than interest rates as a way of dealing with these kinds of risks. But when you look around, it is hard to see what those are, other than building up the capital requirements for commercial banks, which, in itself is a macroprudential policy, does reduce the risk of the banks getting into the kind of trouble that they did before. On the other hand, we have to remember that the banks are just one-third of total capital raising in the United States.
MarketWatch: It seems you were never a big fan of quantitative easing. You don’t want it in the tool kit for the next downturn?
Feldstein: I suppose it comes down to what’s the alternative. If you had said to me before the economic downturn: “What do you think about fiscal policy as a tool for fighting downturns,” I would say that is not a very good tool, we have learned from experience that trying to use discretionary fiscal policy is likely to get us in trouble because we can’t move fast enough. But when this downturn happened, I felt that this is different from previous ones. It was deeper and more importantly, longer, and therefore there was room to do fiscal policy, but the fiscal policy that the administration did in 2009 was just very badly designed and really didn’t do much to stimulate demand.
MarketWatch: And that forced the Fed.
Feldstein: And the Fed came along and said: “Well, if conventional monetary policy won’t do it, and fiscal policy they tried and failed, so it’s up to us now.” And I don’t disagree with that.
MarketWatch: What about other tools to combat downturns — negative rates and raising the 2% inflation target to 4% — you are not a fan?
Feldstein: I am not a fan.
MarketWatch: Let’s take those one at a time — negative rates
Feldstein: Negative rates just provide even more incentive for excessive risk taking. People saying: “Well I can’t get a decent return on a relatively safe asset, so I will take duration risk, I will take credit risk, I will invest in real assets like commercial real estate with exceptionally high prices.” So I think that is not a good thing. And of course in Europe, it is not doing much for them.
MarketWatch: And moving the inflation rate higher?
Feldstein: I am old enough to remember the pain of the inflation in the late 1970s and the early 1980s before Paul Volcker came around and fixed that problem. We paid a high price for getting back to a world where people believe inflation is going to stay low, and if we now come along and say: “Well instead of 2% , let’s go for 4% or 5% because that has certain technical advantages,” then people are going to say: “Oops, what are they going to do next.”
MarketWatch: I hear what you’re saying but maybe I’m not as sanguine as you are. With growth around 2%, couldn’t we end up in a ditch if the Fed does too much?
Feldstein: That’s why, when you asked would I commit to that or would I see how it plays out, I said I must see how it plays out. That’s data-dependent movement.

China’s central bank makes massive cash infusion

590-billion yuan injection is most in 3 years, intended to improve liquidity

Reuters
The headquarters of the People's Bank of China in Beijing.


SHANGHAI — China’s central bank is putting the largest amount of cash into the financial system in nearly three years, using a weekly market operation to pre-empt a holiday-induced funding squeeze and offset rapid capital outflows.
The People’s Bank of China offered 340 billion yuan ($51.89 billion) of short-term loans, known as reverse repurchase agreements, to commercial banks in a routine money market operation Thursday.
The central bank provided 440 billion yuan via similar tools Tuesday, the first leg of its twice-a-week liquidity-management exercises.
Given the maturity of 190 billion yuan of previously issued loans, the PBOC’s net cash injection this week totals 590 billion yuan, the biggest of its kind since early February 2013, when it reached 662 billion yuan.
The move follows an aggressive pump-priming exercise by the PBOC last week, when the central bank offered more than 1.5 trillion yuan in gross short- and medium-term lending to banks.
The eye-popping liquidity injection is partly intended to satisfy typically surging demand for cash ahead of the Lunar New Year holiday that starts Feb. 7.
It also constitutes an effort to stem accelerating capital flight as investors become more nervous about the health of China’s economy, and as the country’s main stock market has lost nearly 23% since the start of this year.

Zika-affected Areas

Where has Zika virus been found?

  • Prior to 2015, Zika virus outbreaks have occurred in areas of Africa, Southeast Asia, and the Pacific Islands.
  • In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil.
  • Currently, outbreaks are occurring in many countries.
  • Zika virus will continue to spread and it will be difficult to determine how the virus will spread over time.
Zika in the United States and its territories:
  • No locally transmitted Zika cases have been reported in the continental United States, but cases have been reported in returning travelers.
  • Locally transmitted Zika virus has been reported in the Commonwealth of Puerto Rico.
  • With the recent outbreaks, the number of Zika cases among travelers visiting or returning to the United States will likely increase.
  • These imported cases could result in local spread of the virus in some areas of the United States.

Countries and territories with active Zika virus transmission

 World map showing countries and territories with reported active transmission of Zika virus (as of January 22, 2016). Countries are listed in the table below.

AMERICAS

  • Barbados
  • Bolivia
  • Brazil
  • Colombia
  • Dominican Republic
  • Ecuador
  • El Salvador
  • French Guiana
  • Guadeloupe
  • Guatemala
  • Guyana
  • Haiti
  • Honduras
  • Martinique
  • Mexico
  • Panama
  • Paraguay
  • Puerto Rico
  • Saint Martin
  • Suriname
  • U.S. Virgin Islands
  • Venezuela

OCEANIA/PACIFIC ISLANDS

  • Samoa

AFRICA

  • Cape Verde

 




Zika Virus Infection


Zika fever is a mosquito-borne viral disease caused by Zika virus (ZIKV), consisting of mild fever, rash (mostly maculo-papular), headaches, arthralgia, myalgia, asthenia, and non-purulent conjunctivitis, occurring about two to seven days after the mosquito vector bite. One out of four people may develop symptoms, but in those who are affected the disease is usually mild with symptoms that can last between two and seven days. Its clinical manifestation is often similar to dengue, also a mosquito-borne illness.
— Frequently Asked Questions about Zika virus/fever
— Question and Answers: Zika and pregnancy
— Provisional remarks on the Zika virus infection in pregnant women: document for health care professionals - 25 January 2016
— Preliminary guidelines for the surveillance of microcephalia in newborns in settings with risk of circulation of the Zika virus - 21 January 2016
— WHO factsheet on Zika virus
— PAHO Statement on Zika Virus Transmission and Prevention
— Information on microcephaly

Countries and territories with Zika autochthonous transmission reported in the Americas Region. Epidemiological Week  (EW) 17 of 2015 to EW 3 of 2016:

Countries and territories with Zika autochthonous transmission reported in the Americas Region. Epidemiological Week  (EW) 17 of 2015 to EW 3 of 2016.Barbados, Bolivia, Brazil, Colombia, Dominican Republic, Ecuador, El Salvador, French Guiana, Guadeloupe, Guatemala, Guyana, Haiti, Honduras, Martinique, Mexico, Panama, Paraguay, Puerto Rico, Saint Martin, Suriname, US Virgin Islands, Venezuela.

Brazil's president declares war on mosquitos to slow spread of Zika virus

220,000 troops to be deployed to scour for mosquito breeding grounds after nearly 4,000 babies since September were born with condition linked to virus
Brazil mosquitos Zika virus infection
Brazilian army soldiers inspect for mosquito breeding sites at a home on 27 January 2016 in Recife, Brazil. Photograph: Mario Tama/Getty Images
President Dilma Rousseff has said that Brazil must wage war against the Aedes aegypti mosquito that spreads the Zika virus, focusing on eliminating the insect’s breeding grounds.
Since September, Brazil has registered nearly 4,000 cases of babies with microcephaly, a condition linked to Zika infection in which children are born with an abnormally small head and a brain that has not developed properly.
The jump in cases has prompted a global health scare, with several countries cautioning pregnant women against traveling to the 22 nations in the Americas where the virus has been reported.
Without a Zika vaccine and with little known about the causes of microcephaly, Brazil has few options available for fighting the spread of the virus and the birth defect.
The mosquito thrives in dense tropical cities, and Rousseff called for the elimination of stagnant water spots where it lives and reproduces.
“We must wage war against the Aedes aegypti, the vector of dengue, of chikungunya and of Zika,” Rousseff said through her Twitter account, referring to two other viral diseases transmitted to humans by the bite of infected mosquitoes.
“While we do not have a vaccine against the Zika virus, the war must be concentrated on the elimination of breeding grounds for the mosquito,” Rousseff added. “Getting rid of Zika is the responsibility of all of us.”
The move comes as Brazil desperately looks to raise awareness of the virus and encourage people to combat the mosquito.
Brazilian health minister Marcelo Castro on Monday promised 220,000 troops would be deployed next month to distribute educational pamphlets and help scour cities for mosquito breeding grounds.
Similar moves have been successful in the past. A huge eradication effort in the 1940s and 1950s, motivated by the spread of yellow fever also carried by Aedes aegypti, led Brazil to be declared free of the mosquito in 1958. But as the program was relaxed, the insect returned.
With Carnival celebrations just over a week away and the Olympic Games set for Rio de Janeiro in August, Brazil is poised to receive hundreds of thousands of visitors in the coming months, adding to concerns over the spread of the virus.